Born Issac Rein in Huttenbach, Bavaria in 1815, he was the son of Hirsch (Tsvi) Rein, a Jewish cattle dealer and merchant. He had at least 6 brothers, all of whom would follow him to America.
The Jews in Bavaria in the early 1800s were both restricted and liberated by The Bavarian Jewish legislation of 1813, which granted Jewish people full citizenship, as well as more rights to worship and travel, it also imposed steep marriage tariffs and regulations. Only one son was permitted to inherit the father's wealth, so a family with multiple sons was at an extreme disadvantage. It is no wonder that many young Jewish men from Bavaria chose to emigrate.
The only person with the surname Rein on board the Brig Dorothea and Louis (or Louise), Isaac would have traveled over land from his home to Bremen, and then by barge to the port of Bremerhaven. While he may have been the only member of his family on the journey, it appears that there were several other Jewish men of similar age also from central Bavaria on the ship. One of them, Carl Blumenthal on the manifest, later Charles Bloomingdale, would become Isaac's business partner for many years. Another Bernard Spatz, served as a witness to Isaac's naturalization. For reasons not yet determined, a number of these young Jewish men settled in Louisville, Kentucky after arriving in America.
Isaac started a business in Louisville and Danville, Kentucky, with his partner Charles Bloomingdale
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